IUCLID Integration Platform


The IUCLID Integration Platform (IIP) from CropLife Europe is a platform to supply additional services for a connected and running IUCLID instance, that the IUCLID web interface does not supply.

Currently, the IIP supports the efficient upload of metadata and attachments for the following IUCLID entities:

  • Literature references (for GLP study reports and publications plus associated metadata)
  • Reference substance

As input, the IIP processes a CSV (Comma separated value) file of a predefined structure - that can for example be generated from Excel or an inhouse reporting tool - plus referenced attachments (like the PDF for study reports). This allows companies to prepare this CSV data from existing inhouse data / systems and then create or update a running IUCLID instance with this information in one batch, without having to manually enter the values in the IUCLID web interface field by field. This ensures better data quality and increases the efficiency of filling IUCLID.

The IIP requires a live connection to a running IUCLID instance and communicates via the REST API (Application Programming Interface) provided by ECHA. Unfortunately, this API is not supported by ECHA for IUCLID instances in the ECHA cloud. Therefore, the IIS has to be used in conjunction with an on-premises installation of IUCLID.

User interface

The following screenshot shows the user interface to upload CSV information to create literature reference entities in IUCLID.

Upload of CSV information

For each of the supported IUCLID entities, the IIP supplies a predefined Excel template plus an example with test data in CSV format - see the "Administration" perspective or check the Download page. The data has to be supplied in this predefined format.

The first row of the Excel / CSV contains the technical names of the fields in IUCLID that are being filled. In the download section you find a Word document for each target IUCLID entity, that contains a tabular description of the entity, explaining each field including the technical field name, as used in the input template. Also, in the attribute mask, when you move the mouse on the type symbol before the label, the field name will be displayed as well, as in the following example:

Each entity in IUCLID can contain single-value fields and multi-value fields (e.g. multiple attachments), the latter either as individual field or as part of a repeating block of fields, like a tabular row. Therefore, the input CSV file can contain multiple lines for one entity, where in each line the different values for one (or many) repeating attributes can be supplied. In order to clearly assign a line in the CSV to one or another entity, the first column of the CSV contains the value for the "primary key" of the respective IUCLID entity. Each line in the Excel belongs to the entity defined by the value of the primary key - or, when the value is not provided, to the preceding entity, where this value was defined in one of the preceding lines before.

The definition of the "primary key" is a definition done by the IIP, not by IUCLID. It allows the IIP to

  • group information from multiple lines into a single entity when creating an entity
  • search for already existing entities in IUCLID to be checked and eventually updated, to avoid the creation of duplicates: Prior to uploading information / attachments, the IIP checks in IUCLID for existing instances with the value of the primary key in the respective field in IUCLID. If an instance is found, the source data and the data in IUCLID is compared and the instance in IUCLID is eventually updated. No duplicates are being created.

The definition of the "primary key" is defined per entity, see the sections further below.

Please note, that the IIP can not process Excel format directly - when coming from the Excel template the worksheet has to be saved in CSV format first.

CSV format

The term "CSV" stands for "comma separated value". More generally it stands for a file, where tabular information is separated by a given delimiter. This format can be generated directly by reporting tools or from Excel. To create a CSV that can be processed by the IIS please consider the following:

  • Please refer to the example files in the CSV example folder (see perspective "Administration) for each entity
  • The only supported delimitor is a semicolon (";"). Please make sure that no data field (e.g. authors) contains this special character.
  • Provide date values in the format YYYY-MM-DD. To avoid that Excel interprets your input and changes it to the local date format, use the prefix ' (apostrophe) before the date value.
  • When you save the data to CSV based on the Excel template, you should save the file using the format option "CSV UTF-8 (comma-delimited) (*.csv)". This sets the character encoding to UTF-8 BOM and preserves also characters outside of ASCII.
  • You can verify your data by opening the resulting CSV file in a texteditor like Notepad++ priot to importing into the IIP. This editor can also show you the encoding.

HowTo Quick Guide

  1. Download, install and start the IIP. Please use the latest versions of Chrome, Edge or Firefox as browser to display the application. Minimize the command window - and do not click inside the window during operation.
  2. In the IIP, in the Administration perspective, enter the information for your IUCLID instance that you want to fill.
    • To connect to the IUCLID instance you have to supply the URL to IUCLID (e.g. "http://<hostname>:<port>" or "https://<hostname>:<port>") and UserName/Password for an existing IUCLID user who has the access rights to create / update the respective IUCLID entities.
  3. Make sure the status information turns to "Connected" after saving, after a 30-60 seconds latest. If not, check the error information in the application or eventually the command window.
  4. Look at the Excel template, the Word definition and the sample data for the IUCLID entity you want to fill. See perspective "Administration" in the running IIP - or you can also download those resources separately on the Download page, if you want to see those file prior to the installation.
  5. Generate your own input data in CSV format based on those examples.
  6. Navigate to the perspective of the entity that you want to upload to (e.g. Literature Reference)
  7. Above the left pane, click on "Import CSV", select your input data and click OK. The left pane will populate and for sucessfully imported jobs the status information in the leftmost column in the left pane will show the job status NEW as icon
  8. To verify the jobs, click on each line to see details on the right pane
  9. When ready, click on "Execute Jobs" above the left pane. The information is now being processed and uploaded to IUCLID. Please note the status information in the leftmost column changing. Use the mouse to hover above the symbols to see their meaning. With the checkbox above the left pane you can hide sucessfully terminated jobs, to only see jobs with error status. For the selected job you see the job details in the lower left part. For successfull jobs you will get the IUCLID UUID identification and can click on this ID to open the instance in IUCLID directly. For errors you will be able to display the available error information.
  10. You can delete the jobs and repeat the above steps with the same CSV - in this case the IIP will detect that IUCLID already contains the correct information. If you change the data in the CSV the entity in IUCLID will be updated

Import IUCLID entities

The first two perspectives in the left bar each support the import of CSV data to create / update a specific IUCLID entity.

Literature reference

The literature reference upload uses the IUCLID field "Study no." (technical field name "GeneralInfo.CompanyOwnerStudyNo") as "primary key".

When active, the demo mode uses the field "Report no." to store the fixed string "Created by IUCLID Integration Platform"

Reference substance

The reference substance upload uses the IUCLID field "Reference substance name" (technical field name "ReferenceSubstanceName") as "primary key.

When active, the demo mode uses the field "IUPAC name" to store the fixed string "Created by IUCLID Integration Platform"

Browse IUCLID entities

The perspective "Browse IUCLID entities" demonstrates the capability of the IIP to read and display arbitrary IUCLID entities dynamically. The masks are not programmed per entity, but dynamically created from the entity definintions retrieved from IUCLID itself. Currently, the entities from the IUCLID inventory are being displayed.

The dynamic mask generation provides a powerful capability to display and manage IUCLID information in an alternate way. A showcase to enter tabular data in a tabular grid has already been created (not part of this current release). Future extensions of the IIP can build upon this capability, 5to provide masks to efficiently input information into IUCLID.


The IIP can serve as platform to support other types of efficient upload into IUCLID. Other showcases have already been prepared, for example making the input of tabular information more efficient by working with state-of-the-art web components for tabular data mangement. Dependent on acceptance and feedback the eSEG group will decide upon further extensions.

As with other CropLife Europe tools, the source code can be requested on demand to collaborate to the development, provided that extensions are made available for the general public again. The CropLife Europe eSEG invites all parties to contribute to and maintain the IIP.